Get Custom Orphan Drug Lists, Seamless Integration, and Automated Updates Without the Stress of Manual Research or Missed Opportunities.

Introducing the Custom




Wasting hours on manual research every quarter
Outdated spreadsheets causing confusion and missed savings
Overwhelmed by unclear compliance requirements
Burned by ineffective tools leaving money on the table
This custom solution was built to remove the complexity and guesswork from orphan drug management. Instead of generic tools or manual tracking, 340B Orphan Drug Solutions delivers a structured, turnkey system that adapts to your facility, works within your existing workflows, and stays current as orphan drug designations and pricing change. Every component is designed to support accuracy, efficiency, and long-term savings.
This flows naturally into:
Tailored Orphan Drug Lists
Seamless Split Billing Integration
Automated Quarterly Updates
Picture a system that automatically tracks orphan drug status, ensuring you never miss a single savings opportunity. No more lost revenue—just a seamless, compliant process.
Say goodbye to compliance worries with a dedicated team keeping your facility audit-ready, so you can focus on patient care without stress.
Stay ahead of price changes with quarterly updates on manufacturer discounts, maximizing savings without endless manual work.


Eliminate tracking errors with fully automated split-billing integration, keeping your reports accurate and preventing financial losses.
Recover thousands effortlessly with a program that proactively identifies missed savings, adding revenue to your facility without extra effort.
Gain expert support every step of the way, ensuring your 340B program runs smoothly and profitably—without the guesswork.

Over a decade of experience managing 340B Orphan Drugs.

Tailored specifically to your facility’s needs.

Quarterly updates and expert guidance for long-term success.
Our Frequently Asked Questions section is designed to provide clear answers to common queries about our services, appointments, treatments, and policies.
• Free Standing Cancer Centers
• Critical Access Hospitals
• Sole Community Hospitals
• Rural Referral Centers
Yes, if you are a qualified entity listed on OPAIS, no matter your location, we cover you!
Absolutely, your hospital data belongs to you and no information will be shared. Ever. We don’t use PPI, so no HIPPA concerns.
Our program will be customized to your needs. We will have an introductory call to exchange information. If you decide to invest in the program to save time, money, and energy, you will be provided a checklist of documentation needed to begin the customization. Sit back, relax, and we take it from there.
That’s a big no. Every hospital has their custom orphan drug portfolio because this is a manufacturer’s discretionary pricing program.
Yes, we do! We are invested in your success. From my heart, I provide this service because I expect nothing less than success, savings, and satisfaction.
Our clients are at the heart of everything we do. Their feedbacks reflect our commitment to providing compassionate care, trusted expertise, and personalized attention.

"I was spending nearly 30 hours each quarter trying to track orphan drug designations and manufacturer discounts. Dr. Nezneski's service cut that down to just a few hours of review time. The automated updates and custom reports have helped us capture an additional $280,000 in savings this year alone."

CEO AND FOUNDER

"As a critical access hospital, we were struggling to keep up with manufacturer discretionary pricing. 340B Orphan Drug Solutions provided us with clear, actionable data that integrated perfectly with our split billing system. Their quarterly updates ensure we never miss an opportunity for savings."

340B Program Manager

"The level of detail and customization in their service is outstanding. Dr. Nezneski worked directly with our team to understand our specific challenges and created a solution that works seamlessly with our existing processes. We've reduced audit preparation time by 75% while increasing our capture rate."

System Pharmacy Director

"What impressed me most was how quickly we saw results. Within the first quarter, we identified several missed opportunities and captured over $125,000 in additional savings. The ongoing support and expertise have been invaluable for our rural health system."

Chief Pharmacy Officer

"Managing orphan drugs across multiple facilities was a constant challenge until we partnered with 340B Orphan Drug Solutions. Their system has streamlined our processes and eliminated the confusion between facilities. The ROI was clear within the first month."

Corporate Director of Pharmacy

"The peace of mind alone is worth the investment. Knowing our orphan drug program is optimized and compliance-ready lets us focus on patient care. Dr. Nezneski's expertise in both 340B and orphan drugs has been a game-changer for our organization."

340B Compliance Officer
Our Commitment to Your Success: If you don't experience a fully streamlined process within your first quarter, we'll provide an additional quarter of dedicated support at no cost to ensure your complete satisfaction.

© 2026 Lisa Nezneski, LLC. All rights reserved.